Protein profile

PA2933

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA2933 Structure source: AlphaFold UniProt Q9HZR4
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Amino acids 392
Annotations 3
Features 49
PDB binders 0
Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession
PA2933
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2933
Status
annotated
Amino acids
392
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
199 217 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
321 343 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
353 375 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
229 251 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
117 127 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
64 69 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
179 198 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
355 376 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
160 179 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
218 228 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
42 64 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 383 PANTHER PTHR43124 PURINE EFFLUX PUMP PBUE
263 285 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
90 94 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 375 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
4 375 InterPro IPR036259 MFS transporter superfamily
151 155 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
71 93 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
289 308 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
128 150 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
263 282 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
309 319 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
128 150 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
200 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 379 SUPERFAMILY SSF103473 MFS general substrate transporter
4 379 InterPro IPR036259 MFS transporter superfamily
344 354 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
320 343 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 39 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 363 CDD cd17324 MFS_NepI_like
70 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
252 262 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
9 340 Pfam PF07690 Major Facilitator Superfamily
9 340 InterPro IPR011701 Major facilitator superfamily
377 392 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
288 308 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 380 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
4 380 InterPro IPR020846 Major facilitator superfamily domain
283 287 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
40 63 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
237 256 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
156 178 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
95 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2933
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.876
6 0.308