Protein profile

PA2942

magnesium chelatase

Genome: NC_002516.2

Gene: PA2942 Structure source: AlphaFold UniProt Q9HZQ5
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Amino acids 338
Annotations 2
Features 17
PDB binders 0
Druggability 0.745

Overview

Basic information about this protein and its source genome.

Accession
PA2942
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2942
Status
annotated
Amino acids
338
Structure source
AlphaFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.745
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSATVHYPLSAVVAADELKLALCLAAVDPAIGGVLIEGPRGMAKSTLARGVAELLPAGEFVTLPLGASEERIVGSLDLDAALGEGRARFSPGVLAKADGGVLYVDEVNLLPDHLVDLLLDVAASGVNLVERDGISHRHPARFVLIGTMNPEEGELRPQLLDRFGLNVRLDTQPPPAERAEIIRRRLAFDADPQAFVERWEGQQDTLRRRCAEARRRLARIPLDDAALDSIARRCFEAAVDGLRADLVWLRAARAHAAWRGGERIEAEDIDAVEHFALLHRRRQSNPPPSAANPPPPPAAAPVALPERTGDGEGQWGELPARPVAMGTARELPRWPKKP

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
30 192 SMART SM00382 AAA_5
30 192 InterPro IPR003593 AAA+ ATPase domain
33 163 Pfam PF07728 AAA domain (dynein-related subfamily)
33 163 InterPro IPR011704 ATPase, dynein-related, AAA domain
287 302 MobiDBLite mobidb-lite consensus disorder prediction
13 170 CDD cd00009 AAA
5 58 PANTHER PTHR32039 MAGNESIUM-CHELATASE SUBUNIT CHLI
5 58 InterPro IPR045006 Magnesium-chelatase subunit ChlI-like
215 295 Gene3D G3DSA:1.10.8.80 -
278 338 MobiDBLite mobidb-lite consensus disorder prediction
5 169 Gene3D G3DSA:3.40.50.300 -
5 169 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
229 287 Pfam PF17863 AAA lid domain
229 287 InterPro IPR041628 ChlI/MoxR, AAA lid domain
196 216 Coils Coil Coil
6 283 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
6 283 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2942
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.745