Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2945
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2945 cobW
Status: annotated
Amino acids: 375
Structure source: AlphaFold

EC

3.6.5.-

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 48.718
Human E-value: 3.13e-15
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.655

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

3.6.5.-

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
295	374	Pfam	PF07683	Cobalamin synthesis protein cobW C-terminal domain
295	374	InterPro	IPR011629	Zinc chaperone CobW-like, C-terminal
179	194	MobiDBLite	mobidb-lite	consensus disorder prediction
283	374	SMART	SM00833	CobW_C_3
283	374	InterPro	IPR011629	Zinc chaperone CobW-like, C-terminal
293	374	SUPERFAMILY	SSF90002	Hypothetical protein YjiA, C-terminal domain
31	267	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
31	267	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
264	373	Gene3D	G3DSA:3.30.1220.10	-
264	373	InterPro	IPR036627	CobW-like, C-terminal domain superfamily
29	257	Gene3D	G3DSA:3.40.50.300	-
29	257	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
172	194	MobiDBLite	mobidb-lite	consensus disorder prediction
27	373	PANTHER	PTHR13748	COBW-RELATED
33	256	CDD	cd03112	CobW-like
30	370	NCBIfam	TIGR02475	cobalamin biosynthesis protein CobW
30	370	InterPro	IPR012824	Zinc chaperone CobW
264	283	MobiDBLite	mobidb-lite	consensus disorder prediction
33	240	Pfam	PF02492	CobW/HypB/UreG, nucleotide-binding domain
33	240	InterPro	IPR003495	CobW/HypB/UreG, nucleotide-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2945	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.655
1				0.371

PA2945