Protein profile

PA2947

hypothetical protein

Genome: NC_002516.2

Gene: PA2947 Structure source: Experimental + AlphaFold UniProt Q9HZQ0
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Amino acids 142
Annotations 1
Features 7
PDB binders 0
Druggability 0.535

Overview

Basic information about this protein and its source genome.

Accession
PA2947
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2947
Status
annotated
Amino acids
142
Structure source
Experimental + AlphaFold
GO
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.535
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
9 133 Pfam PF01890 Cobalamin synthesis G C-terminus
9 133 InterPro IPR002750 CobE/GbiG C-terminal domain
2 142 Gene3D G3DSA:3.30.420.180 -
2 142 InterPro IPR036518 CobE/GbiG C-terminal domain superfamily
3 135 PANTHER PTHR37477 COBALT-PRECORRIN-5A HYDROLASE
4 134 SUPERFAMILY SSF159664 CobE/GbiG C-terminal domain-like
4 134 InterPro IPR036518 CobE/GbiG C-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2W6K
X-ray 1.70 Å A
100.0% 1-142
PDBe RCSB PDBj File
Viewing
PDB 2W6L
X-ray 1.89 Å A
100.0% 1-142
PDBe RCSB PDBj File
Loaded
AlphaFold PA2947
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.535

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.57 0.655
2 0.53 0.0