Protein profile

PA2956

hypothetical protein

Genome: NC_002516.2

Gene: PA2956 Structure source: AlphaFold UniProt Q9HZP2
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Amino acids 298
Annotations 3
Features 17
PDB binders 0
Druggability 0.838

Overview

Basic information about this protein and its source genome.

Accession
PA2956
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2956
Status
annotated
Amino acids
298
Structure source
AlphaFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.838
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
21 206 Gene3D G3DSA:3.20.20.70 Aldolase class I
21 206 InterPro IPR013785 Aldolase-type TIM barrel
22 237 SMART SM00729 MiaB
22 237 InterPro IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain
6 202 SFLD SFLDS00029 Radical SAM
6 202 InterPro IPR007197 Radical SAM
8 296 SFLD SFLDS00029 Radical SAM
8 296 InterPro IPR007197 Radical SAM
17 256 PANTHER PTHR43409 ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED
26 236 CDD cd01335 Radical_SAM
18 246 ProSiteProfiles PS51918 Radical SAM core domain profile.
18 246 InterPro IPR007197 Radical SAM
8 296 SFLD SFLDG01095 Uncharacterised Radical SAM Subgroup 7
6 210 SUPERFAMILY SSF102114 Radical SAM enzymes
6 202 SFLD SFLDG01082 B12-binding domain containing
27 184 Pfam PF04055 Radical SAM superfamily
27 184 InterPro IPR007197 Radical SAM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2956
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.838