Protein profile

PA2957

transcriptional regulator

Genome: NC_002516.2

Gene: PA2957 Structure source: Experimental + AlphaFold UniProt Q9HZP1
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Amino acids 212
Annotations 4
Features 16
PDB binders 0
Druggability 0.616

Overview

Basic information about this protein and its source genome.

Accession
PA2957
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2957
Status
annotated
Amino acids
212
Structure source
Experimental + AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.616
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
87 195 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
87 195 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
12 72 ProSiteProfiles PS50977 TetR-type HTH domain profile.
12 72 InterPro IPR001647 DNA-binding HTH domain, TetR-type
87 194 Pfam PF13305 Tetracyclin repressor-like, C-terminal domain
87 194 InterPro IPR025996 Tetracyclin repressor-like, C-terminal domain (WHG)
18 63 Pfam PF00440 Bacterial regulatory proteins, tetR family
18 63 InterPro IPR001647 DNA-binding HTH domain, TetR-type
2 192 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
9 76 SUPERFAMILY SSF46689 Homeodomain-like
9 76 InterPro IPR009057 Homeobox-like domain superfamily
18 31 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
18 31 InterPro IPR001647 DNA-binding HTH domain, TetR-type
39 62 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
39 62 InterPro IPR001647 DNA-binding HTH domain, TetR-type
9 190 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7W2Q
X-ray 1.80 Å A,B
100.0% 1-212
PDBe RCSB PDBj File
Viewing
PDB 7W2O
X-ray 3.21 Å A,C
100.0% 1-212
PDBe RCSB PDBj File
Loaded
AlphaFold PA2957
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.616
3 0.201

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.4 0.753
2 3.99 0.159