Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2970
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2970 rpmF
Status: annotated
Amino acids: 60
Structure source: AlphaFold

GO

GO:0022625 The large subunit of a ribosome located in the cytosol. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0015934 The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.521

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0022625 The large subunit of a ribosome located in the cytosol.
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
GO:0015934 The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
1	60	MobiDBLite	mobidb-lite	consensus disorder prediction
2	56	Pfam	PF01783	Ribosomal L32p protein family
2	56	InterPro	IPR002677	Ribosomal protein L32p
33	60	MobiDBLite	mobidb-lite	consensus disorder prediction
1	56	PANTHER	PTHR35534	50S RIBOSOMAL PROTEIN L32
1	56	InterPro	IPR044957	Ribosomal protein L32p, bacterial type
2	55	SUPERFAMILY	SSF57829	Zn-binding ribosomal proteins
2	55	InterPro	IPR011332	Zinc-binding ribosomal protein
9	24	MobiDBLite	mobidb-lite	consensus disorder prediction
2	54	NCBIfam	TIGR01031	50S ribosomal protein L32
2	54	InterPro	IPR002677	Ribosomal protein L32p
1	54	Hamap	MF_00340	50S ribosomal protein L32 [rpmF].
1	54	InterPro	IPR002677	Ribosomal protein L32p

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2970	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.521

PA2970