Protein profile

PA2977

UDP-N-acetylenolpyruvoylglucosamine reductase

Genome: NC_002516.2

Gene: murB PA2977 Structure source: Experimental + AlphaFold UniProt Q9HZM7
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Amino acids 339
Annotations 9
Features 22
PDB binders 4
Druggability 0.617

Overview

Basic information about this protein and its source genome.

Accession
PA2977
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
murB PA2977
Status
annotated
Amino acids
339
Structure source
Experimental + AlphaFold
EC
1.3.1.98
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0008762 Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.617
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
  • GO:0008762 Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
  • GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
10 197 SUPERFAMILY SSF56176 FAD-binding/transporter-associated domain-like
10 197 InterPro IPR036318 FAD-binding, type PCMH-like superfamily
216 338 Pfam PF02873 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
216 338 InterPro IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal
212 338 SUPERFAMILY SSF56194 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
212 338 InterPro IPR036635 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain superfamily
11 335 NCBIfam TIGR00179 UDP-N-acetylmuramate dehydrogenase
11 335 InterPro IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase
25 156 Pfam PF01565 FAD binding domain
25 156 InterPro IPR006094 FAD linked oxidase, N-terminal
229 339 Gene3D G3DSA:3.90.78.10 -
229 339 InterPro IPR036635 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain superfamily
1 339 Hamap MF_00037 UDP-N-acetylenolpyruvoylglucosamine reductase [murB].
1 339 InterPro IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase
1 74 Gene3D G3DSA:3.30.43.10 -
1 74 InterPro IPR016167 FAD-binding, type PCMH, subdomain 1
75 228 Gene3D G3DSA:3.30.465.10 -
75 228 InterPro IPR016169 FAD-binding, type PCMH, subdomain 2
4 338 PANTHER PTHR21071 UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
4 338 InterPro IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase
18 189 ProSiteProfiles PS51387 PCMH-type FAD-binding domain profile.
18 189 InterPro IPR016166 FAD-binding domain, PCMH-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7OSQ
X-ray 2.07 Å A
100.0% 1-339
PDBe RCSB PDBj File
Viewing
PDB 4JB1
X-ray 2.10 Å A
100.0% 1-339
PDBe RCSB PDBj File
Loaded
PDB 4JAY
X-ray 2.23 Å A,B,C,D
100.0% 1-339
PDBe RCSB PDBj File
Loaded
PDB 7ORZ
X-ray 1.85 Å A
99.4% 3-339
PDBe RCSB PDBj File
Loaded
PDB 7OR2
X-ray 2.35 Å A
99.4% 3-339
PDBe RCSB PDBj File
Loaded
AlphaFold PA2977
AlphaFold — — full sequence — Loaded
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Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

39 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

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Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
B3P
4JAY 2.23 Å Open crystal
282.3 Da LogP -4.01 TPSA 145.4 1 viol. ✓ Clean C(CNC(CO)(CO)CO)CNC(CO)(CO)CO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.