Protein profile

PA2984

hypothetical protein

Genome: NC_002516.2

Gene: PA2984 Structure source: AlphaFold UniProt Q9HZM0
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Amino acids 741
Annotations 3
Features 50
PDB binders 0
Druggability 0.745

Overview

Basic information about this protein and its source genome.

Accession
PA2984
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2984
Status
annotated
Amino acids
741
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030420 The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.745
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MRLGLPALAAGLLALRFLAELPSVGWLLGMAAAGLLLLFGRLYWLGLFLLGFAWACGSAQVALDGRLAAELDGRTLWLEGRVVDLPASGEGVTRFRLEEVSAARGVLLPERLRLSWRGAPPLMGGERWRLAVTLKRPRGLVNAAGFDYEAWLLAQRVGAVGTVKAGQRLQPASGLDAWRDAWRQRLLAVDAQGRGAALAALVLGDGSGLSAAEWRMFQDTGTVHLMVISGSHISLLAGMLYGLVAALHRLGCWPRRLPWLPCACALGLLGAWSYGLMAGFEVPVRRACLMVSLALVWRLRFRHLGLLTPLLATLVLVLLVEPLASLQAGFWLSFLAVALLLWLFAGRLGRWRWWAAWGRAQWGMALGLAMPLLALGLPLSLSGAPANLLAVPWIELLVVPPALAGSLLLWVPGLGEGLLRAAGVSLDLLFRALGLLAGLAEAWQPPAAAAWSVALGMLGALCWLAPAGLPLRALGAALLLPALLPSSPPVEWGRAEVRVLDVGQGLAVLVRTREHVLLYDSGARQGAFDMGERVVVPVLRSLDLRRLDGLLLSHADNDHAGGAPTVASRFPPVWLVSGEPARLPSPLFADSCDERSWSWDGVVFEQWAWAQAGDSNDRSCVLRVEADGEVLLLTGDISRAAEHAWLARQADPRVDWLLAPHHGSRSSSGVAFVLRTRPRHVLVSRGWRNAFGHPHGEVMERYARVAAQVHDTARDGALTFLLGSRGGARRERDSAHFWREK

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0030420 The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
466 741 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
493 725 Gene3D G3DSA:3.60.15.10 -
493 725 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
247 257 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
418 440 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 716 NCBIfam TIGR00361 DNA internalization-related competence protein ComEC/Rec2
122 716 InterPro IPR004797 Competence protein ComEC/Rec2
496 662 CDD cd07731 ComA-like_MBL-fold
496 662 InterPro IPR035681 ComA-like, MBL domain
258 280 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 168 Pfam PF13567 Domain of unknown function (DUF4131)
21 168 InterPro IPR025405 Domain of unknown function DUF4131
225 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 41 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
390 411 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
201 464 Pfam PF03772 Competence protein
201 464 InterPro IPR004477 ComEC/Rec2-related protein
225 246 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
257 276 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
362 384 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
281 300 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
365 384 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
301 320 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
501 666 Pfam PF00753 Metallo-beta-lactamase superfamily
501 666 InterPro IPR001279 Metallo-beta-lactamase
389 411 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
42 63 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
447 469 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
304 326 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 739 PANTHER PTHR30619 DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2
64 224 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
504 687 SMART SM00849 Lactamase_B_5a
504 687 InterPro IPR001279 Metallo-beta-lactamase
496 721 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
496 721 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
330 349 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
222 400 NCBIfam TIGR00360 ComEC/Rec2-related protein
222 400 InterPro IPR004477 ComEC/Rec2-related protein
441 445 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
412 417 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
326 345 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
446 465 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
321 325 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
346 364 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
385 389 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2984
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.745
16 0.35