Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2997
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: nqrC PA2997
Status: annotated
Amino acids: 261
Structure source: AlphaFold

EC

7.2.1.1

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.786

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

7.2.1.1

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
146	244	Pfam	PF04205	FMN-binding domain
146	244	InterPro	IPR007329	FMN-binding
21	28	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	261	PANTHER	PTHR37838	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT C
1	261	InterPro	IPR010204	Na(+)-translocating NADH-quinone reductase subunit C
1	28	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
146	247	SMART	SM00900	FMN_bind_2
146	247	InterPro	IPR007329	FMN-binding
5	259	Hamap	MF_00427	Na(+)-translocating NADH-quinone reductase subunit C [nqrC].
5	259	InterPro	IPR010204	Na(+)-translocating NADH-quinone reductase subunit C
10	32	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
5	255	NCBIfam	TIGR01938	NADH:ubiquinone reductase (Na(+)-transporting) subunit C
5	255	InterPro	IPR010204	Na(+)-translocating NADH-quinone reductase subunit C
10	20	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	261	PIRSF	PIRSF009437	NQR-1_subunit_C
1	28	Phobius	SIGNAL_PEPTIDE	Signal peptide region
29	261	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2997	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.786
1				0.634

PA2997