Protein profile

PA2999

Na(+)-translocating NADH-quinone reductase subunit A

Genome: NC_002516.2

Gene: nqrA PA2999 Structure source: AlphaFold UniProt Q9HZK6
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Amino acids 445
Annotations 3
Features 9
PDB binders 0
Druggability 0.257

Overview

Basic information about this protein and its source genome.

Accession
PA2999
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
nqrA PA2999
Status
annotated
Amino acids
445
Structure source
AlphaFold
EC
7.2.1.1
GO
GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.257
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 255 Pfam PF05896 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)
1 255 InterPro IPR008703 Na(+)-translocating NADH-quinone reductase subunit A
2 445 NCBIfam TIGR01936 NADH:ubiquinone reductase (Na(+)-transporting) subunit A
2 445 InterPro IPR008703 Na(+)-translocating NADH-quinone reductase subunit A
1 445 Hamap MF_00425 Na(+)-translocating NADH-quinone reductase subunit A [nqrA].
1 445 InterPro IPR008703 Na(+)-translocating NADH-quinone reductase subunit A
1 445 PANTHER PTHR37839 NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A
260 309 Pfam PF11973 NQRA C-terminal domain
260 309 InterPro IPR022615 Na(+)-translocating NADH-quinone reductase subunit A, C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2999
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.257
5 0.213