Protein profile

PA3008

cell division inhibitor SulA

Genome: NC_002516.2

Gene: sulA PA3008 Structure source: Experimental + AlphaFold UniProt Q9HZJ8
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Amino acids 161
Annotations 4
Features 7
PDB binders 0
Druggability 0.572

Overview

Basic information about this protein and its source genome.

Accession
PA3008
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
sulA PA3008
Status
annotated
Amino acids
161
Structure source
Experimental + AlphaFold
GO
GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0051782 Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0009432 An error-prone process for repairing damaged microbial DNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.572
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
  • GO:0051782 Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
  • GO:0009432 An error-prone process for repairing damaged microbial DNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
47 133 Pfam PF03846 Cell division inhibitor SulA
47 133 InterPro IPR004596 Cell division suppressor protein, SulA
45 159 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
45 159 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
43 161 Gene3D G3DSA:3.40.50.300 -
43 161 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
5 159 PANTHER PTHR35369 BLR3025 PROTEIN-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1OFT
X-ray 2.90 Å A,B,C,D
100.0% 1-161
PDBe RCSB PDBj File
Viewing
PDB 1OFU
X-ray 2.10 Å X,Y
73.9% 43-161
PDBe RCSB PDBj File
Loaded
AlphaFold PA3008
AlphaFold — — full sequence — Loaded
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