Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3023
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3023
Status: annotated
Amino acids: 302
Structure source: AlphaFold

EC

2.7.1.-

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0001727 Catalysis of the phosphorylation of a simple or complex lipid. GO:0000287 Binding to a magnesium (Mg) ion. GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.836

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 10 GO

Enzyme Commission (EC)

1

2.7.1.-

Gene Ontology (GO)

10

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0001727 Catalysis of the phosphorylation of a simple or complex lipid.
GO:0000287 Binding to a magnesium (Mg) ion.
GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
GO:0006665 The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
GO:0046872 Binding to a metal ion.
GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
5	295	NCBIfam	TIGR03702	lipid kinase YegS
5	295	InterPro	IPR022433	Lipid kinase YegS
124	295	PANTHER	PTHR47233	CHEMOTAXIS PROTEIN CHEV
8	290	NCBIfam	TIGR00147	YegS/Rv2252/BmrU family lipid kinase
8	290	InterPro	IPR005218	Diacylglycerol/lipid kinase
12	125	Pfam	PF00781	Diacylglycerol kinase catalytic domain
12	125	InterPro	IPR001206	Diacylglycerol kinase, catalytic domain
5	296	Hamap	MF_01377	Probable lipid kinase YegS [yegS].
5	296	InterPro	IPR022433	Lipid kinase YegS
4	291	SUPERFAMILY	SSF111331	NAD kinase/diacylglycerol kinase-like
4	291	InterPro	IPR016064	NAD kinase/diacylglycerol kinase-like domain superfamily
6	125	SMART	SM00046	dagk_c4a_7
6	125	InterPro	IPR001206	Diacylglycerol kinase, catalytic domain
5	124	Gene3D	G3DSA:3.40.50.10330	-
5	124	InterPro	IPR017438	Inorganic polyphosphate/ATP-NAD kinase, N-terminal
1	129	ProSiteProfiles	PS50146	DAG-kinase catalytic (DAGKc) domain profile.
1	129	InterPro	IPR001206	Diacylglycerol kinase, catalytic domain
145	286	Pfam	PF19279	YegS C-terminal NAD kinase beta sandwich-like domain
145	286	InterPro	IPR045540	YegS/DAGK, C-terminal domain
125	281	Gene3D	G3DSA:2.60.200.40	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3023	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.836

PA3023