Protein profile

PA3034

transcriptional regulator

Genome: NC_002516.2

Gene: PA3034 Structure source: AlphaFold UniProt Q9HZH4
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Amino acids 185
Annotations 4
Features 15
PDB binders 1
Druggability 0.85

Overview

Basic information about this protein and its source genome.

Accession
PA3034
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3034
Status
annotated
Amino acids
185
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.85
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 185 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
3 76 SUPERFAMILY SSF46689 Homeodomain-like
3 76 InterPro IPR009057 Homeobox-like domain superfamily
3 180 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
53 73 Coils Coil Coil
9 54 Pfam PF00440 Bacterial regulatory proteins, tetR family
9 54 InterPro IPR001647 DNA-binding HTH domain, TetR-type
3 63 ProSiteProfiles PS50977 TetR-type HTH domain profile.
3 63 InterPro IPR001647 DNA-binding HTH domain, TetR-type
76 180 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
76 180 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
30 53 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
30 53 InterPro IPR001647 DNA-binding HTH domain, TetR-type
9 22 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
9 22 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3034
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.85

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NPO
2I10
Q0RX74 139.1 Da LogP 1.30 TPSA 63.4 ✓ Ro5 ✓ Clean c1cc(ccc1[N+](=O)[O-])O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.