Protein profile

PA3037

hypothetical protein

Genome: NC_002516.2

Gene: PA3037 Structure source: AlphaFold UniProt Q9HZH1
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Amino acids 288
Annotations 2
Features 17
PDB binders 0
Druggability 0.808

Overview

Basic information about this protein and its source genome.

Accession
PA3037
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3037
Status
annotated
Amino acids
288
Structure source
AlphaFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.808
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
52 272 Pfam PF00753 Metallo-beta-lactamase superfamily
52 272 InterPro IPR001279 Metallo-beta-lactamase
25 284 Gene3D G3DSA:3.60.15.10 -
25 284 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
33 273 CDD cd07730 metallo-hydrolase-like_MBL-fold
22 288 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
54 272 SMART SM00849 Lactamase_B_5a
54 272 InterPro IPR001279 Metallo-beta-lactamase
18 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
48 276 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
48 276 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
14 283 PANTHER PTHR42978 QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3037
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.808