Protein profile

PA3060

pellicle/biofilm biosynthesis protein PelE

Genome: NC_002516.2

Gene: pelE PA3060 Structure source: AlphaFold UniProt Q9HZE8
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Amino acids 329
Annotations 1
Features 15
PDB binders 0
Druggability 0.801

Overview

Basic information about this protein and its source genome.

Accession
PA3060
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pelE PA3060
Status
annotated
Amino acids
329
Structure source
AlphaFold
GO
GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.801
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
33 53 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
65 93 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
260 280 Coils Coil Coil
66 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 32 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
122 247 Gene3D G3DSA:1.25.10.10 -
122 247 InterPro IPR011989 Armadillo-like helical
54 64 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
94 329 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3060
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.801
1 0.739
3 0.683
9 0.582