Protein profile

PA3061

pellicle/biofilm biosynthesis protein PelD

Genome: NC_002516.2

Gene: PA3061 pelD Structure source: Experimental + AlphaFold UniProt Q9HZE7
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Amino acids 455
Annotations 3
Features 21
PDB binders 1
Druggability 0.77

Overview

Basic information about this protein and its source genome.

Accession
PA3061
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3061 pelD
Status
annotated
Amino acids
455
Structure source
Experimental + AlphaFold
GO
GO:0035438 Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.77
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0035438 Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
84 88 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
319 455 Gene3D G3DSA:3.30.70.2880 -
319 455 InterPro IPR038367 PelD, GGDEF domain superfamily
88 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
42 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
62 81 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
181 304 Pfam PF13492 GAF domain
181 304 InterPro IPR003018 GAF domain
16 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
65 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
181 313 SUPERFAMILY SSF55781 GAF domain-like
37 41 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
321 444 Pfam PF16963 PelD GGDEF domain
321 444 InterPro IPR031583 PelD, GGDEF domain
59 64 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 15 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155 318 Gene3D G3DSA:3.30.450.40 -
155 318 InterPro IPR029016 GAF-like domain superfamily
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
89 108 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
109 455 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4ETX
X-ray 2.00 Å A
65.9% 155-454
PDBe RCSB PDBj File
Viewing
PDB 4EU0
X-ray 1.70 Å A
65.5% 158-455
PDBe RCSB PDBj File
Loaded
PDB 4EUV
X-ray 2.00 Å A
65.3% 158-454
PDBe RCSB PDBj File
Loaded
PDB 4ETZ
X-ray 2.05 Å A,B
65.3% 158-454
PDBe RCSB PDBj File
Loaded
AlphaFold PA3061
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
C2E
4DN0
A0A0H2ZD98 690.4 Da LogP -3.05 TPSA 349.6 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@@](=O…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.