Protein profile

PA3063

pellicle/biofilm biosynthesis protein PelB

Genome: NC_002516.2

Gene: PA3063 pelB Structure source: Experimental + AlphaFold UniProt Q9HZE5
Export view
Amino acids 1193
Annotations 2
Features 17
PDB binders 0
Druggability 0.771

Overview

Basic information about this protein and its source genome.

Accession
PA3063
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3063 pelB
Status
annotated
Amino acids
1193
Structure source
Experimental + AlphaFold
GO
GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.771
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
187 353 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
187 353 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
362 523 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
362 523 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
593 728 SUPERFAMILY SSF48452 TPR-like
593 728 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
532 857 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
532 857 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
56 345 SUPERFAMILY SSF48452 TPR-like
56 345 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
447 727 Pfam PF13429 Tetratricopeptide repeat
1 18 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
19 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
37 1193 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58 100 Pfam PF14559 Tetratricopeptide repeat
1 962 PANTHER PTHR45586 TPR REPEAT-CONTAINING PROTEIN PA4667

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5WFT
X-ray 2.82 Å A
9.9% 319-436
PDBe RCSB PDBj File
Viewing
AlphaFold PA3063
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.771
2 0.412

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.91 0.004