Protein profile

PA3068

NAD-specific glutamate dehydrogenase

Genome: NC_002516.2

Gene: gdhB PA3068 Structure source: AlphaFold UniProt Q9HZE0
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Amino acids 1620
Annotations 5
Features 13
PDB binders 0
Druggability 0.476

Overview

Basic information about this protein and its source genome.

Accession
PA3068
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
gdhB PA3068
Status
annotated
Amino acids
1620
Structure source
AlphaFold
EC
1.4.1.2
GO
GO:0004352 Catalysis of the reaction: L-glutamate + NAD+ + H2O = 2-oxoglutarate + NH4+ + NADH + H+. GO:0004069 Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. GO:0006538 The chemical reactions and pathways resulting in the breakdown of L-glutamate. GO:0019551 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.476
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0004352 Catalysis of the reaction: L-glutamate + NAD+ + H2O = 2-oxoglutarate + NH4+ + NADH + H+.
  • GO:0004069 Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
  • GO:0006538 The chemical reactions and pathways resulting in the breakdown of L-glutamate.
  • GO:0019551 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
951 1245 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
951 1245 InterPro IPR036291 NAD(P)-binding domain superfamily
761 962 SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain
761 962 InterPro IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily
7 1615 PANTHER PTHR43403 NAD-SPECIFIC GLUTAMATE DEHYDROGENASE
7 1615 InterPro IPR007780 NAD-glutamate dehydrogenase, bacteria
77 1607 Pfam PF05088 Bacterial NAD-glutamate dehydrogenase
77 1607 InterPro IPR028971 NAD-glutamate dehydrogenase
944 1242 Gene3D G3DSA:3.40.50.720 -
2 1614 PIRSF PIRSF036761 GDH_Mll4104
2 1614 InterPro IPR007780 NAD-glutamate dehydrogenase, bacteria
717 737 Coils Coil Coil
1227 1247 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3068
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.33
2 0.311