Protein profile

PA3074

hypothetical protein

Genome: NC_002516.2

Gene: PA3074 Structure source: AlphaFold UniProt Q9HZD4
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Amino acids 586
Annotations 1
Features 32
PDB binders 0
Druggability 0.916

Overview

Basic information about this protein and its source genome.

Accession
PA3074
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3074
Status
annotated
Amino acids
586
Structure source
AlphaFold
GO
GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.916
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
40 57 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 39 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
363 477 SUPERFAMILY SSF48452 TPR-like
363 477 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
410 441 Pfam PF00515 Tetratricopeptide repeat
410 441 InterPro IPR001440 Tetratricopeptide repeat 1
15 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
461 494 MobiDBLite mobidb-lite consensus disorder prediction
65 84 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
409 442 ProSiteProfiles PS50005 TPR repeat profile.
409 442 InterPro IPR019734 Tetratricopeptide repeat
58 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
107 204 Pfam PF13519 von Willebrand factor type A domain
107 204 InterPro IPR002035 von Willebrand factor, type A
315 342 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
97 287 Gene3D G3DSA:3.40.50.410 von Willebrand factor, type A domain
97 287 InterPro IPR036465 von Willebrand factor A-like domain superfamily
85 314 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
361 474 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
361 474 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
343 586 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
409 442 SMART SM00028 tpr_5
442 481 Coils Coil Coil
12 28 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
461 586 MobiDBLite mobidb-lite consensus disorder prediction
118 138 Coils Coil Coil
2 583 PANTHER PTHR22550 SPORE GERMINATION PROTEIN
409 441 ProSiteProfiles PS50293 TPR repeat region circular profile.
63 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 233 SUPERFAMILY SSF53300 vWA-like
102 233 InterPro IPR036465 von Willebrand factor A-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3074
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.916
1 0.827
3 0.235