Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3078
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3078
Status: annotated
Amino acids: 431
Structure source: AlphaFold

EC

2.7.13.3

GO

GO:0000155 Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.901

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

2.7.13.3

Gene Ontology (GO)

2

GO:0000155 Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
306	427	SUPERFAMILY	SSF55874	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
306	427	InterPro	IPR036890	Histidine kinase/HSP90-like ATPase superfamily
164	186	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
339	430	SMART	SM00387	HKATPase_4
339	430	InterPro	IPR003594	Histidine kinase/HSP90-like ATPase
27	162	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
305	431	Gene3D	G3DSA:3.30.565.10	-
305	431	InterPro	IPR036890	Histidine kinase/HSP90-like ATPase superfamily
1	5	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
186	297	Gene3D	G3DSA:1.10.287.130	-
163	185	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
186	431	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
235	299	SMART	SM00388	HisKA_10
235	299	InterPro	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
233	295	CDD	cd00082	HisKA
233	295	InterPro	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
237	297	Pfam	PF00512	His Kinase A (phospho-acceptor) domain
237	297	InterPro	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
218	295	SUPERFAMILY	SSF47384	Homodimeric domain of signal transducing histidine kinase
218	295	InterPro	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
207	368	PANTHER	PTHR43547	TWO-COMPONENT HISTIDINE KINASE
4	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
6	26	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
242	430	ProSiteProfiles	PS50109	Histidine kinase domain profile.
242	430	InterPro	IPR005467	Histidine kinase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3078	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.901
2				0.507
11				0.364

PA3078