Protein profile

PA3079

hypothetical protein

Genome: NC_002516.2

Gene: PA3079 Structure source: AlphaFold UniProt Q9HZC9
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Amino acids 793
Annotations 2
Features 46
PDB binders 0
Druggability 0.774

Overview

Basic information about this protein and its source genome.

Accession
PA3079
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3079
Status
annotated
Amino acids
793
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.774
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

46 records
Show feature table
Start End DB Term Name
651 673 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
578 784 Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain
198 401 Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain
446 625 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
725 745 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
268 290 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
339 360 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
372 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
674 678 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
751 778 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
361 371 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
699 724 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
677 699 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
295 312 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
757 779 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
375 397 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
268 393 ProSiteProfiles PS50156 Sterol-sensing domain (SSD) profile.
268 393 InterPro IPR000731 Sterol-sensing domain
725 742 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 266 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
479 777 Pfam PF03176 MMPL family
479 777 InterPro IPR004869 Membrane transport protein MMPL domain
338 360 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
626 644 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
239 261 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
426 445 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
679 698 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
289 293 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
651 673 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
626 644 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 395 SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain
238 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
779 793 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
645 650 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 781 PANTHER PTHR33406 MEMBRANE PROTEIN MJ1562-RELATED
313 338 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
746 750 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
294 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
426 445 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
397 425 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
40 237 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
579 779 SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3079
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.709
2 0.203