Protein profile

PA3097

type II secretion system protein K

Genome: NC_002516.2

Gene: PA3097 xcpX Structure source: Experimental + AlphaFold UniProt Q00518
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Amino acids 333
Annotations 5
Features 24
PDB binders 0
Druggability 0.573

Overview

Basic information about this protein and its source genome.

Accession
PA3097
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3097 xcpX
Status
annotated
Amino acids
333
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009306 The controlled release of proteins from a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.573
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009306 The controlled release of proteins from a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 333 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 311 NCBIfam NF037980 type II secretion system minor pseudopilin GspK
5 311 InterPro IPR005628 General secretion pathway protein K
7 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
106 215 Gene3D G3DSA:1.10.40.60 -
106 215 InterPro IPR038072 GspK, central domain superfamily
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 314 PANTHER PTHR38831 TYPE II SECRETION SYSTEM PROTEIN K
3 314 InterPro IPR005628 General secretion pathway protein K
314 333 MobiDBLite mobidb-lite consensus disorder prediction
1 316 PIRSF PIRSF002786 XcpX
1 316 InterPro IPR005628 General secretion pathway protein K
216 272 SUPERFAMILY SSF158544 GspK insert domain-like
216 272 InterPro IPR038072 GspK, central domain superfamily
38 314 SUPERFAMILY SSF54523 Pili subunits
38 314 InterPro IPR045584 Pilin-like
108 214 SUPERFAMILY SSF158544 GspK insert domain-like
108 214 InterPro IPR038072 GspK, central domain superfamily
30 307 Pfam PF03934 Type II secretion system (T2SS), protein K
30 307 InterPro IPR005628 General secretion pathway protein K
216 275 Gene3D G3DSA:1.10.40.60 -
216 275 InterPro IPR038072 GspK, central domain superfamily
45 300 Gene3D G3DSA:3.30.1300.30 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5VTM
X-ray 2.04 Å X
82.0% 44-316
PDBe RCSB PDBj File
Viewing
PDB 6UTU
X-ray 2.85 Å C,F,I
82.0% 44-316
PDBe RCSB PDBj File
Loaded
AlphaFold PA3097
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.573
4 0.38

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.7 0.08
2 2.07 0.046