Protein profile

PA3102

type II secretion system protein F

Genome: NC_002516.2

Gene: PA3102 xcpS Structure source: AlphaFold UniProt Q00513
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Amino acids 405
Annotations 6
Features 34
PDB binders 1
Druggability 0.944

Overview

Basic information about this protein and its source genome.

Accession
PA3102
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3102 xcpS
Status
annotated
Amino acids
405
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0046872 Binding to a metal ion. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009306 The controlled release of proteins from a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.944
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
  • GO:0046872 Binding to a metal ion.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009306 The controlled release of proteins from a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
57 173 FunFam G3DSA:1.20.81.30:FF:000001 Type II secretion system protein F
244 376 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 404 PANTHER PTHR30012 GENERAL SECRETION PATHWAY PROTEIN
1 404 InterPro IPR003004 GspF/PilC family
377 399 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 79 PRINTS PR00812 Bacterial general secretion pathway protein F signature
67 79 InterPro IPR003004 GspF/PilC family
385 404 PRINTS PR00812 Bacterial general secretion pathway protein F signature
385 404 InterPro IPR003004 GspF/PilC family
166 194 PRINTS PR00812 Bacterial general secretion pathway protein F signature
166 194 InterPro IPR003004 GspF/PilC family
369 383 PRINTS PR00812 Bacterial general secretion pathway protein F signature
369 383 InterPro IPR003004 GspF/PilC family
257 367 Gene3D G3DSA:1.20.81.30 Type II secretion system (T2SS), domain F
257 367 InterPro IPR042094 Type II secretion system GspF domain superfamily
223 243 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 404 NCBIfam TIGR02120 type II secretion system inner membrane protein GspF
4 404 InterPro IPR011850 Type II secretion system protein GspF
1 169 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
169 191 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
224 243 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
399 405 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
274 396 Pfam PF00482 Type II secretion system (T2SS), protein F
274 396 InterPro IPR018076 Type II secretion system protein GspF domain
72 194 Pfam PF00482 Type II secretion system (T2SS), protein F
72 194 InterPro IPR018076 Type II secretion system protein GspF domain
194 222 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
166 194 ProSitePatterns PS00874 Bacterial type II secretion system protein F signature.
166 194 InterPro IPR001992 T2SS_GspF/T4SS_PilC conserved site
377 398 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
170 193 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 173 Gene3D G3DSA:1.20.81.30 Type II secretion system (T2SS), domain F
56 173 InterPro IPR042094 Type II secretion system GspF domain superfamily
257 370 FunFam G3DSA:1.20.81.30:FF:000001 Type II secretion system protein F

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3102
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.944
2 0.574
1 0.252

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
PE5
3C1Q
P45780 398.5 Da LogP 0.13 TPSA 94.1 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.