Protein profile

PA3115

motility protein FimV

Genome: NC_002516.2

Gene: fimV PA3115 Structure source: Experimental + AlphaFold UniProt Q9HZA6
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Amino acids 919
Annotations 5
Features 38
PDB binders 0
Druggability 0.228

Overview

Basic information about this protein and its source genome.

Accession
PA3115
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fimV PA3115
Status
annotated
Amino acids
919
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.228
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
  • GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records
Show feature table
Start End DB Term Name
319 367 Coils Coil Coil
269 283 MobiDBLite mobidb-lite consensus disorder prediction
327 898 PANTHER PTHR18898 NUCLEOPROTEIN TPR-RELATED
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
174 229 ProSiteProfiles PS51782 LysM domain profile.
174 229 InterPro IPR018392 LysM domain
163 238 Gene3D G3DSA:3.10.350.10 LysM domain
163 238 InterPro IPR036779 LysM domain superfamily
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
485 919 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
25 463 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
175 230 SMART SM00257 LysM_2
175 230 InterPro IPR018392 LysM domain
411 445 MobiDBLite mobidb-lite consensus disorder prediction
182 254 NCBIfam TIGR03505 FimV/HubP N-terminal domain
182 254 InterPro IPR020012 Motility protein FimV, N-terminal
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
463 485 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
766 848 MobiDBLite mobidb-lite consensus disorder prediction
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
232 311 MobiDBLite mobidb-lite consensus disorder prediction
858 919 Gene3D G3DSA:1.20.58.2200 -
858 919 InterPro IPR038440 FimV, C-terminal domain superfamily
140 177 MobiDBLite mobidb-lite consensus disorder prediction
551 607 SUPERFAMILY SSF48452 TPR-like
551 607 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
380 394 MobiDBLite mobidb-lite consensus disorder prediction
232 259 MobiDBLite mobidb-lite consensus disorder prediction
372 445 MobiDBLite mobidb-lite consensus disorder prediction
547 626 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
547 626 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
875 918 NCBIfam TIGR03504 FimV/HubP C-terminal domain
875 918 InterPro IPR020011 Motility protein FimV, C-terminal
464 484 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
175 229 CDD cd00118 LysM
175 229 InterPro IPR018392 LysM domain
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4MBQ
X-ray 2.01 Å A,B,C,D,E,F
6.3% 862-919
PDBe RCSB PDBj File
Viewing
PDB 4MAL
X-ray 2.05 Å A,B
6.3% 862-919
PDBe RCSB PDBj File
Loaded
AlphaFold PA3115
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.228