Protein profile

PA3120

isopropylmalate isomerase small subunit

Genome: NC_002516.2

Gene: PA3120 leuD Structure source: AlphaFold UniProt Q9HZA4
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Amino acids 212
Annotations 4
Features 13
PDB binders 0
Druggability 0.619

Overview

Basic information about this protein and its source genome.

Accession
PA3120
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3120 leuD
Status
annotated
Amino acids
212
Structure source
AlphaFold
EC
4.2.1.33
GO
GO:0009316 A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. GO:0003861 Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. GO:0009098 The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.619
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0009316 A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
  • GO:0003861 Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
  • GO:0009098 The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 188 FunFam G3DSA:3.20.19.10:FF:000003 3-isopropylmalate dehydratase small subunit
14 154 CDD cd01577 IPMI_Swivel
14 154 InterPro IPR033940 3-isopropylmalate dehydratase, swivel domain
1 210 Hamap MF_01031 3-isopropylmalate dehydratase small subunit [leuD].
1 210 InterPro IPR004431 3-isopropylmalate dehydratase, small subunit
1 196 NCBIfam TIGR00171 3-isopropylmalate dehydratase small subunit
1 196 InterPro IPR004431 3-isopropylmalate dehydratase, small subunit
1 188 Gene3D G3DSA:3.20.19.10 Aconitase, domain 4
1 188 InterPro IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
3 203 PANTHER PTHR43345 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED
1 132 Pfam PF00694 Aconitase C-terminal domain
1 132 InterPro IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
1 203 SUPERFAMILY SSF52016 LeuD/IlvD-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3120
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.619