Protein profile

PA3122

transcriptional regulator

Genome: NC_002516.2

Gene: PA3122 Structure source: AlphaFold UniProt Q9HZA2
Export view
Amino acids 297
Annotations 3
Features 21
PDB binders 6

Overview

Basic information about this protein and its source genome.

Accession
PA3122
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3122
Status
annotated
Amino acids
297
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 86 Gene3D G3DSA:1.10.10.10 -
1 86 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
39 50 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
39 50 InterPro IPR000847 Transcription regulator HTH, LysR
29 39 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
29 39 InterPro IPR000847 Transcription regulator HTH, LysR
18 29 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
18 29 InterPro IPR000847 Transcription regulator HTH, LysR
3 62 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
3 62 InterPro IPR000847 Transcription regulator HTH, LysR
1 110 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
1 110 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 58 ProSiteProfiles PS50931 LysR-type HTH domain profile.
1 58 InterPro IPR000847 Transcription regulator HTH, LysR
87 288 Pfam PF03466 LysR substrate binding domain
87 288 InterPro IPR005119 LysR, substrate-binding
1 288 PANTHER PTHR30126 HTH-TYPE TRANSCRIPTIONAL REGULATOR
92 285 CDD cd05466 PBP2_LTTR_substrate
86 289 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
93 293 Gene3D G3DSA:3.40.190.290 -
1 84 FunFam G3DSA:1.10.10.10:FF:000001 LysR family transcriptional regulator

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model PA3122 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3122
AlphaFold — — full sequence — Viewing

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AKG
5Y2V
P73862 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
OAS
4LQ2
P06614 147.1 Da LogP -1.04 TPSA 89.6 ✓ Ro5 ✓ Clean CC(=O)OC[C@@H](C(=O)O)N
PEO
4X6G
Q9HTL4 34.0 Da LogP 0.02 TPSA 40.5 ✓ Ro5 ✓ Clean OO
RUB
5Z49
Q9F1R2 310.1 Da LogP -2.50 TPSA 191.0 1 viol. ✓ Clean C([C@H]([C@H](C(=O)COP(=O)(O)O)O)O)OP(=O)(O)O
SAC
4M4G
P06614 147.1 Da LogP -1.43 TPSA 86.6 ✓ Ro5 ✓ Clean CC(=O)N[C@@H](CO)C(=O)O
SKM
5TED
Q8Y9N7 174.2 Da LogP -1.52 TPSA 98.0 ✓ Ro5 ✓ Clean C1[C@H]([C@@H]([C@@H](C=C1C(=O)O)O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.