Protein profile

PA3133

transcriptional regulator

Genome: NC_002516.2

Gene: PA3133 Structure source: Experimental + AlphaFold UniProt Q9HZ91
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Amino acids 180
Annotations 2
Features 15
PDB binders 0
Druggability 0.903

Overview

Basic information about this protein and its source genome.

Accession
PA3133
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3133
Status
annotated
Amino acids
180
Structure source
Experimental + AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0048023 Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.903
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0048023 Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
49 180 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
12 58 Pfam PF00440 Bacterial regulatory proteins, tetR family
12 58 InterPro IPR001647 DNA-binding HTH domain, TetR-type
33 56 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
33 56 InterPro IPR001647 DNA-binding HTH domain, TetR-type
12 25 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
12 25 InterPro IPR001647 DNA-binding HTH domain, TetR-type
1 48 Gene3D G3DSA:1.10.10.60 -
1 178 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
78 179 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
78 179 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
6 66 ProSiteProfiles PS50977 TetR-type HTH domain profile.
6 66 InterPro IPR001647 DNA-binding HTH domain, TetR-type
1 70 SUPERFAMILY SSF46689 Homeodomain-like
1 70 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2FD5
X-ray 1.70 Å A
100.0% 1-180
PDBe RCSB PDBj File
Viewing
AlphaFold PA3133
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.903
3 0.3

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.04 0.769
2 0.92 0.004