Protein profile

PA3136

secretion protein

Genome: NC_002516.2

Gene: PA3136 Structure source: AlphaFold UniProt Q9HZ89
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Amino acids 355
Annotations 1
Features 19
PDB binders 0
Druggability 0.512

Overview

Basic information about this protein and its source genome.

Accession
PA3136
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3136
Status
annotated
Amino acids
355
Structure source
AlphaFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.512
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
56 115 SUPERFAMILY SSF111369 HlyD-like secretion proteins
128 189 SUPERFAMILY SSF111369 HlyD-like secretion proteins
184 218 Coils Coil Coil
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
340 355 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
68 88 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
41 355 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
57 126 Gene3D G3DSA:2.40.50.100 -
31 350 Pfam PF00529 Cation efflux system protein CusB domain 1
31 350 InterPro IPR043602 Cation efflux system protein CusB, domain 1
237 354 Gene3D G3DSA:2.40.30.170 -
97 117 Coils Coil Coil
198 295 SUPERFAMILY SSF111369 HlyD-like secretion proteins
13 355 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
55 297 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
55 297 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
127 190 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3136
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.512