Protein profile

PA3147

glycosyl transferase WbpJ

Genome: NC_002516.2

Gene: wbpJ PA3147 Structure source: AlphaFold UniProt Q9HZ80

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Amino acids 413

Annotations 3

Features 13

PDB binders 0

Druggability 0.848

Overview

Basic information about this protein and its source genome.

Accession: PA3147
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: wbpJ PA3147
Status: annotated
Amino acids: 413
Structure source: AlphaFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.848

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
22	202	Pfam	PF13439	Glycosyltransferase Family 4
22	202	InterPro	IPR028098	Glycosyltransferase subfamily 4-like, N-terminal domain
76	98	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
230	372	Pfam	PF13692	Glycosyl transferases group 1
1	213	Gene3D	G3DSA:3.40.50.2000	Glycogen Phosphorylase B;
79	98	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
89	405	PANTHER	PTHR45947	SULFOQUINOVOSYL TRANSFERASE SQD2
2	404	CDD	cd03794	GT4_WbuB-like
99	413	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3	407	SUPERFAMILY	SSF53756	UDP-Glycosyltransferase/glycogen phosphorylase
105	127	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	78	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
214	390	Gene3D	G3DSA:3.40.50.2000	Glycogen Phosphorylase B;

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3147	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.848
1				0.208