Protein profile

PA3167

3-phosphoserine/phosphohydroxythreonine aminotransferase

Genome: NC_002516.2

Gene: PA3167 serC Structure source: Experimental + AlphaFold UniProt Q9HZ66
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Amino acids 361
Annotations 7
Features 20
PDB binders 4
Druggability 0.7

Overview

Basic information about this protein and its source genome.

Accession
PA3167
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3167 serC
Status
annotated
Amino acids
361
Structure source
Experimental + AlphaFold
EC
2.6.1.52
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004648 Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006564 The chemical reactions and pathways resulting in the formation of L-serine. GO:0008615 The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
50.137
Human E-value
4.97e-130
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.7
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004648 Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
  • GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
  • GO:0006564 The chemical reactions and pathways resulting in the formation of L-serine.
  • GO:0008615 The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
18 251 Gene3D G3DSA:3.40.640.10 -
18 251 InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major domain
4 359 SUPERFAMILY SSF53383 PLP-dependent transferases
4 359 InterPro IPR015424 Pyridoxal phosphate-dependent transferase
3 360 Hamap MF_00160 Phosphoserine aminotransferase [serC].
3 360 InterPro IPR022278 Phosphoserine aminotransferase
1 361 PIRSF PIRSF000525 SerC
1 361 InterPro IPR022278 Phosphoserine aminotransferase
252 361 Gene3D G3DSA:3.90.1150.10 Aspartate Aminotransferase, domain 1
252 361 InterPro IPR015422 Pyridoxal phosphate-dependent transferase, small domain
6 349 Pfam PF00266 Aminotransferase class-V
6 349 InterPro IPR000192 Aminotransferase class V domain
6 358 CDD cd00611 PSAT_like
6 358 InterPro IPR022278 Phosphoserine aminotransferase
2 360 PANTHER PTHR43247 PHOSPHOSERINE AMINOTRANSFERASE
2 360 InterPro IPR022278 Phosphoserine aminotransferase
258 361 FunFam G3DSA:3.90.1150.10:FF:000006 Phosphoserine aminotransferase
6 360 NCBIfam TIGR01364 phosphoserine transaminase
6 360 InterPro IPR022278 Phosphoserine aminotransferase
17 257 FunFam G3DSA:3.40.640.10:FF:000010 Phosphoserine aminotransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4XK1
X-ray 2.15 Å A,B
100.0% 1-361
PDBe RCSB PDBj File
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AlphaFold PA3167
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.7

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.2 0.11
2 2.35 0.061
3 1.25 0.012
4 1.22 0.011
5 1.05 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

43 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
GAM
1BJO
P23721 161.2 Da LogP -0.35 TPSA 100.6 ✓ Ro5 ✓ Clean C[C@](CCC(=O)O)(C(=O)O)N
PC4
2FYF
P9WQ73 336.9 Da LogP 2.76 TPSA 0.0 ✓ Ro5 ✓ Clean Cl[Pt-2](Cl)(Cl)Cl
PMP
6CZY
Q96255 248.2 Da LogP 0.16 TPSA 125.9 ✓ Ro5 ✓ Clean Cc1c(c(c(cn1)COP(=O)(O)O)CN)O
SEP
4AZJ
Q9RME2 185.1 Da LogP -1.49 TPSA 130.1 ✓ Ro5 ✓ Clean C([C@@H](C(=O)O)N)OP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.