Protein profile

PA3170

N-ethylammeline chlorohydrolase

Genome: NC_002516.2

Gene: PA3170 Structure source: Experimental + AlphaFold UniProt Q9HZ64
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Amino acids 444
Annotations 6
Features 17
PDB binders 7
Druggability 0.652

Overview

Basic information about this protein and its source genome.

Accession
PA3170
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3170
Status
annotated
Amino acids
444
Structure source
Experimental + AlphaFold
GO
GO:0090614 Catalysis of the reaction: S-methyl-5'-thioadenosine + H2O + H+ = S-methyl-5'-thioinosine + NH4+. GO:0004000 Catalysis of the reaction: adenosine + H2O = inosine + NH4+. GO:0019239 Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R). GO:0046872 Binding to a metal ion. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
29.375
Human E-value
3.54e-13
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.652
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0090614 Catalysis of the reaction: S-methyl-5'-thioadenosine + H2O + H+ = S-methyl-5'-thioinosine + NH4+.
  • GO:0004000 Catalysis of the reaction: adenosine + H2O = inosine + NH4+.
  • GO:0019239 Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
  • GO:0046872 Binding to a metal ion.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
67 357 Gene3D G3DSA:3.20.20.140 -
67 357 FunFam G3DSA:3.20.20.140:FF:000014 5-methylthioadenosine/S-adenosylhomocysteine deaminase
66 365 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
66 365 InterPro IPR032466 Metal-dependent hydrolase
26 420 CDD cd01298 ATZ_TRZ_like
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 441 PANTHER PTHR43794 AMINOHYDROLASE SSNA-RELATED
23 444 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
15 431 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
15 431 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
64 412 Pfam PF01979 Amidohydrolase family
64 412 InterPro IPR006680 Amidohydrolase-related
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
9 438 SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases
9 438 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4GBD
X-ray 1.98 Å A,B
100.0% 1-444
PDBe RCSB PDBj File
Viewing
PDB 4DYK
X-ray 2.00 Å A,B
100.0% 1-444
PDBe RCSB PDBj File
Loaded
AlphaFold PA3170
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.652
2 0.651

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.09 0.895
2 1.0 0.005

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

60 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
MCF
4GBD 1.98 Å Open crystal
314.4 Da LogP -0.84 TPSA 112.1 ✓ Ro5 ✓ Clean CSC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2N=CNC[C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.