Protein profile

PA3176

glutamate/sodium ion symporter GltS

Genome: NC_002516.2

Gene: gltS PA3176 Structure source: AlphaFold UniProt Q9HZ58
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Amino acids 404
Annotations 4
Features 44
PDB binders 0
Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession
PA3176
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
gltS PA3176
Status
annotated
Amino acids
404
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015501 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). GO:0015813 The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015501 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).
  • GO:0015813 The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records
Show feature table
Start End DB Term Name
66 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
246 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
220 239 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 34 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 65 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
340 364 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
161 185 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
335 339 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
249 266 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
311 334 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 400 NCBIfam TIGR00210 sodium/glutamate symporter
5 400 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
240 245 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 370 Pfam PF03616 Sodium/glutamate symporter
4 370 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
186 219 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
90 95 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
378 400 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
365 375 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 403 Hamap MF_02062 Sodium/glutamate symporter [gltS].
3 403 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
278 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 277 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
341 363 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
279 297 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
67 89 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
401 404 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
376 400 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
121 125 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
312 334 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
220 239 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 401 PANTHER PTHR36178 SLR0625 PROTEIN
1 401 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 52 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
158 180 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 23 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
300 310 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 23 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
150 160 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
126 149 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3176
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.906
1 0.596