Overview
Basic information about this protein and its source genome.
- Accession
- PA3194
- Gene
- edd PA3194
- Status
- annotated
- Amino acids
- 608
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Enzyme Commission (EC)
1Gene Ontology (GO)
8- GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
- GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
- GO:0046872 Binding to a metal ion.
- GO:0004456 Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O.
- GO:0019521 The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.
- GO:0009255 A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.
- GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
- GO:0016836 Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 24 | 601 | PANTHER | PTHR43661 | D-XYLONATE DEHYDRATASE |
| 419 | 600 | SUPERFAMILY | SSF52016 | LeuD/IlvD-like |
| 154 | 164 | ProSitePatterns | PS00886 | Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. |
| 154 | 164 | InterPro | IPR020558 | Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site |
| 419 | 568 | Gene3D | G3DSA:3.50.30.80 | - |
| 419 | 568 | InterPro | IPR042096 | Dihydroxy-acid dehydratase, C-terminal |
| 505 | 516 | ProSitePatterns | PS00887 | Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. |
| 505 | 516 | InterPro | IPR020558 | Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site |
| 1 | 418 | SUPERFAMILY | SSF143975 | IlvD/EDD N-terminal domain-like |
| 1 | 418 | InterPro | IPR037237 | IlvD/EDD, N-terminal domain |
| 1 | 601 | Hamap | MF_02094 | Phosphogluconate dehydratase [edd]. |
| 1 | 601 | InterPro | IPR004786 | 6-phosphogluconate dehydratase |
| 419 | 568 | FunFam | G3DSA:3.50.30.80:FF:000001 | Dihydroxy-acid dehydratase |
| 66 | 597 | Pfam | PF00920 | Dehydratase family |
| 66 | 597 | InterPro | IPR000581 | Dihydroxy-acid/6-phosphogluconate dehydratase |
| 2 | 601 | NCBIfam | TIGR01196 | phosphogluconate dehydratase |
| 2 | 601 | InterPro | IPR004786 | 6-phosphogluconate dehydratase |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA3194
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 2 | 0.77 | ||||||
| 3 | 0.388 | ||||||
| 1 | 0.282 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| FES | B5ZZ34 | 175.8 Da LogP 1.29 TPSA 0.0 | ✓ Ro5 | ✓ Clean |
S1[Fe]S[Fe]1
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
No virtual-screening candidates for this protein.
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.