Protein target profile

PA3197

hypothetical protein

Genome: NC_002516.2

Gene: PA3197 3D evidence: AlphaFold DB model UniProt Q9HZ43
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Length 332
Pocket druggability 0.695
EC / GO 0 / 2
Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

3 signals

Strengths

No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Moderate predicted binding pocket FPocket selected-pocket score 0.69. This supports review but is not experimental validation. Structure available AlphaFold DB model

Risks / watch

No major risk signal surfaced in the loaded evidence.

Missing evidence

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.
How to read this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal TPW pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Overview

Basic information about this protein and its source genome.

Accession
PA3197
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3197
Status
annotated
Amino acids
332
3D evidence
AlphaFold DB model
GO
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0051304 The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
Hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected pocket evidence

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.695
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MNLSDPHELATLLEGILLAAGKPLSLERLAELFDEAERPEPGQFRDALAILALSCAGRSFELKEVASGYRLQIRERFSPWVGRLWEERPQRYSRALLETLVLIAYRQPITRGEIEEIRGVAVNTQIVKTLMEREWIRIVGYREVPGRPAMLATTKAFLDYFNLKSLDELPPLSALREMEPEPEPPVEVAPAAQPPRDDLDEDAIPASIQALADRAIAEAGESLEEIEGEAGEPEKPREETSFRSLLLELDEMEQGLKTDFDDLLDPPEPSEQGDESAEPAAGPIPVVAEQAVEPAVAEAVAGADPDDEERALAEAMREEREALDADDDWPRR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0051304 The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
88 182 Gene3D G3DSA:1.10.10.10 -
88 182 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
5 86 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
5 86 InterPro IPR036390 Winged helix DNA-binding domain superfamily
87 163 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
87 163 InterPro IPR036390 Winged helix DNA-binding domain superfamily
229 264 MobiDBLite mobidb-lite consensus disorder prediction
303 332 MobiDBLite mobidb-lite consensus disorder prediction
1 183 PANTHER PTHR34298 SEGREGATION AND CONDENSATION PROTEIN B
1 183 InterPro IPR005234 Chromosome segregation/condensation protein ScpB
8 174 NCBIfam TIGR00281 SMC-Scp complex subunit ScpB
8 174 InterPro IPR005234 Chromosome segregation/condensation protein ScpB
2 87 Gene3D G3DSA:1.10.10.10 -
2 87 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
12 172 Pfam PF04079 Segregation and condensation complex subunit ScpB
12 172 InterPro IPR005234 Chromosome segregation/condensation protein ScpB
172 332 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold DB PA3197
AlphaFold DB — — full sequence — Viewing
Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1
0.695
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