Protein profile

PA3210

potassium uptake protein TrkH

Genome: NC_002516.2

Gene: PA3210 trkH Structure source: AlphaFold UniProt Q9HZ30
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Amino acids 484
Annotations 9
Features 38
PDB binders 0
Druggability 0.693

Overview

Basic information about this protein and its source genome.

Accession
PA3210
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3210 trkH
Status
annotated
Amino acids
484
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0015079 Enables the transfer of potassium ions (K+) from one side of a membrane to the other. GO:0015379 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). GO:0071805 A process in which a potassium ion is transported from one side of a membrane to the other. GO:0008324 Enables the transfer of cation from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.693
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MALPTLRILGFIIGIFLITLAASMLVPILTMLAFDRTEGIQAFIWSSVATFVTGLGLVLPGRPEHVHLRPRDMYMLTVSSWVLVCIFAALPFVLQQHISYTDAFFESMSGITATGSTVLSGLDDMSPGILIWRSLLHWLGGIGFIAMAVAILPMLRIGGMRLFQTESSDRSEKVLPRSHMVAKYIVATYVGITLLGSLAFWGAGMSPFDAVNHAMSAISTGGFSTSDQSLAKWKQPAVHWTAVVVMILGSLPFALYVATLRGHRKALIKDQQVRGLLGLLLVTWLLMGTWYAVTSKLPWMDAFRIVAVNVTSVVTTTGFALGDYSMWGHFSIMLFFYLGFIGGCSGSTAGGIKIFRFQVAYTLLKANLYQLIHPRAVLKQNYNGHRLDEEIVRSILTFSFFFAIVVCLLALGLSLIGLDWMTALTGAASTVAGVGPGMGPIIGPSGNFASLPDAAKWLLAAGMLLGRLEIITVLVLLTPAFWRH

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0015079 Enables the transfer of potassium ions (K+) from one side of a membrane to the other.
  • GO:0015379 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
  • GO:0071805 A process in which a potassium ion is transported from one side of a membrane to the other.
  • GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006812 The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records
Show feature table
Start End DB Term Name
273 295 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
160 179 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
305 327 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 484 PANTHER PTHR32024 TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
73 95 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
395 416 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
180 203 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
73 94 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
420 442 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 134 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
334 355 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
457 482 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
138 160 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
391 413 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 159 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
273 293 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
262 272 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
294 333 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
356 394 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 484 PIRSF PIRSF006247 TrkH
1 484 InterPro IPR004772 TrkH potassium transport family
237 261 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
181 203 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
41 476 Pfam PF02386 Cation transport protein
41 476 InterPro IPR003445 Cation transporter
204 236 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
417 456 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
483 484 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
238 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
457 479 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 39 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3210
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.693
3 0.607