Protein profile

PA3219

hypothetical protein

Genome: NC_002516.2

Gene: PA3219 Structure source: AlphaFold UniProt Q9HZ21
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Amino acids 270
Annotations 4
Features 10
PDB binders 0
Druggability 0.827

Overview

Basic information about this protein and its source genome.

Accession
PA3219
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3219
Status
annotated
Amino acids
270
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872 Binding to a metal ion. GO:0008758 Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.827
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0046872 Binding to a metal ion.
  • GO:0008758 Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP.
  • GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
18 232 CDD cd07398 MPP_YbbF-LpxH
11 265 PANTHER PTHR34990 UDP-2,3-DIACYLGLUCOSAMINE HYDROLASE-RELATED
11 265 InterPro IPR043461 UDP-2,3-diacylglucosamine hydrolase LpxH-like
13 261 Gene3D G3DSA:3.60.21.10 -
13 261 InterPro IPR029052 Metallo-dependent phosphatase-like
17 231 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain
17 231 InterPro IPR024654 Calcineurin-like phosphoesterase domain, lpxH-type
15 253 SUPERFAMILY SSF56300 Metallo-dependent phosphatases
15 253 InterPro IPR029052 Metallo-dependent phosphatase-like
13 260 FunFam G3DSA:3.60.21.10:FF:000029 UDP-2,3-diacylglucosamine hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3219
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.827
6 0.22