Protein profile

PA3232

DNA polymerase III subunit epsilon

Genome: NC_002516.2

Gene: PA3232 Structure source: AlphaFold UniProt Q9HZ08
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Amino acids 208
Annotations 4
Features 10
PDB binders 0
Druggability 0.686

Overview

Basic information about this protein and its source genome.

Accession
PA3232
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3232
Status
annotated
Amino acids
208
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0003676 Binding to a nucleic acid. GO:0006259 Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.686
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MNTMVKLPDSRWPGWRRRLYWWMHEAVEAEEVISLDLETTSLDPRRADILSIGAVLVRRGKLVMGERLELYVEPPPSLDAESIRIHKLRRADLEGQLQLEQALRQVLAFIGDRPLLGYYLSFDVAVLNRHLRQLLDRQLHNPSIEISSLYHRKVSRHFPDAHIDLRFDTLARALDVPVSGRHTALGDAQAVALMFMRLLKGPAPKVIH

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0006259 Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
22 201 SUPERFAMILY SSF53098 Ribonuclease H-like
22 201 InterPro IPR012337 Ribonuclease H-like superfamily
30 195 PANTHER PTHR30231 DNA POLYMERASE III SUBUNIT EPSILON
25 202 Gene3D G3DSA:3.30.420.10 -
25 202 InterPro IPR036397 Ribonuclease H superfamily
34 194 Pfam PF00929 Exonuclease
34 194 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III
33 196 CDD cd06127 DEDDh
31 204 SMART SM00479 exoiiiendus
31 204 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3232
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.686
1 0.439