Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3233
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3233
Status: annotated
Amino acids: 599
Structure source: AlphaFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0015095 Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.836

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).
GO:0015095 Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records

Show feature table

Start	End	DB	Term	Name
335	446	CDD	cd05401	NT_GlnE_GlnD_like
214	273	ProSiteProfiles	PS51371	CBS domain profile.
214	273	InterPro	IPR000644	CBS domain
8	138	Gene3D	G3DSA:2.60.120.10	Jelly Rolls
8	138	InterPro	IPR014710	RmlC-like jelly roll fold
143	276	Gene3D	G3DSA:3.10.580.10	-
143	276	InterPro	IPR046342	CBS domain superfamily
11	127	SMART	SM00100	cnmp_10
11	127	InterPro	IPR000595	Cyclic nucleotide-binding domain
156	199	Pfam	PF00571	CBS domain
156	199	InterPro	IPR000644	CBS domain
222	263	Pfam	PF00571	CBS domain
222	263	InterPro	IPR000644	CBS domain
9	135	SUPERFAMILY	SSF51206	cAMP-binding domain-like
9	135	InterPro	IPR018490	Cyclic nucleotide-binding domain superfamily
149	263	CDD	cd04589	CBS_pair_CAP-ED_NT_Pol-beta-like_DUF294_assoc
11	119	CDD	cd00038	CAP_ED
11	119	InterPro	IPR000595	Cyclic nucleotide-binding domain
11	126	ProSiteProfiles	PS50042	cAMP/cGMP binding motif profile.
11	126	InterPro	IPR000595	Cyclic nucleotide-binding domain
290	420	Pfam	PF03445	Putative nucleotidyltransferase DUF294
290	420	InterPro	IPR005105	Protein-PII uridylyltransferase, N-terminal
31	111	Pfam	PF00027	Cyclic nucleotide-binding domain
31	111	InterPro	IPR000595	Cyclic nucleotide-binding domain
153	264	SUPERFAMILY	SSF54631	CBS-domain pair
153	264	InterPro	IPR046342	CBS domain superfamily
458	594	Pfam	PF10335	Putative nucleotidyltransferase substrate binding domain
458	594	InterPro	IPR018821	Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding
124	265	PANTHER	PTHR43080	CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3233	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
11				0.836
6				0.413

PA3233