Protein profile

PA3245

cell division topological specificity factor MinE

Genome: NC_002516.2

Gene: minE PA3245 Structure source: AlphaFold UniProt Q9HYZ5
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Amino acids 84
Annotations 5
Features 11
PDB binders 0
Druggability 0.832

Overview

Basic information about this protein and its source genome.

Accession
PA3245
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
minE PA3245
Status
annotated
Amino acids
84
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042802 Binding to an identical protein or proteins. GO:0000918 The process of marking the site where a division septum will form. GO:0032955 Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.832
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0042802 Binding to an identical protein or proteins.
  • GO:0000918 The process of marking the site where a division septum will form.
  • GO:0032955 Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 83 Gene3D G3DSA:3.30.1070.10 Cell division topological specificity factor MinE
1 83 InterPro IPR036707 Cell division topological specificity factor MinE superfamily
1 83 FunFam G3DSA:3.30.1070.10:FF:000001 Cell division topological specificity factor
15 82 Pfam PF03776 Septum formation topological specificity factor MinE
15 82 InterPro IPR005527 Cell division topological specificity factor MinE
33 83 SUPERFAMILY SSF55229 Cell division protein MinE topological specificity domain
33 83 InterPro IPR036707 Cell division topological specificity factor MinE superfamily
3 84 Hamap MF_00262 Cell division topological specificity factor [minE].
3 84 InterPro IPR005527 Cell division topological specificity factor MinE
1 83 NCBIfam TIGR01215 cell division topological specificity factor MinE
1 83 InterPro IPR005527 Cell division topological specificity factor MinE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3245
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.832