Protein profile

PA3263

recombination associated protein RdgC

Genome: NC_002516.2

Gene: PA3263 rdgC Structure source: Experimental + AlphaFold UniProt Q9HYX7
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Amino acids 306
Annotations 5
Features 7
PDB binders 0
Druggability 0.839

Overview

Basic information about this protein and its source genome.

Accession
PA3263
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3263 rdgC
Status
annotated
Amino acids
306
Structure source
Experimental + AlphaFold
GO
GO:0043590 The region of a bacterial cell to which the DNA is confined. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003690 Binding to double-stranded DNA. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0000018 Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.839
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0043590 The region of a bacterial cell to which the DNA is confined.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0003690 Binding to double-stranded DNA.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0000018 Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
1 300 Pfam PF04381 Putative exonuclease, RdgC
1 300 InterPro IPR007476 Putative exonuclease, RdgC
1 304 PANTHER PTHR38103 RECOMBINATION-ASSOCIATED PROTEIN RDGC
1 304 InterPro IPR007476 Putative exonuclease, RdgC
1 302 Hamap MF_00194 Recombination-associated protein RdgC [rdgC].
1 302 InterPro IPR007476 Putative exonuclease, RdgC
90 110 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2OWY
X-ray 2.50 Å A,B
100.0% 1-306
PDBe RCSB PDBj File
Viewing
AlphaFold PA3263
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.839