Protein profile

PA3310

hypothetical protein

Genome: NC_002516.2

Gene: PA3310 Structure source: AlphaFold UniProt Q9HYT4
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Amino acids 551
Annotations 6
Features 28
PDB binders 4
Druggability 0.745

Overview

Basic information about this protein and its source genome.

Accession
PA3310
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3310
Status
annotated
Amino acids
551
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016776 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.745
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MGGGIKRFLPAIGSTRLVMLFALVLVVFYNAATWKALHGLVPLQGLKGFAFFASFAAFLWAAFTLLLTLVSFRPLLKPALTLVALCSAGATYFMGSYGISIDTVMVQNVFETNATEAGDLVNPTLLGYLLLLGVLPSLLIWLWPVRYRPFFRGLLNKILTLLGCLLIVAVMVGSFYSTYAPIFREEDKLTHFINPTNYIYAVGKYAKQRLVIKEHLVVEPIGLDARQAPAALQRQKKSLLVFVVGETARADHFSLNGYARETNPELSKQDIVNFTQVRSCGTSTAVSVPCMFSQYPREDYSDKKAKTHEGLLDILQRAGVQVLWLENNSDCKGTCLRVPNRDIPKTQPSPFCDGKNCLDESLLVGLQEYIDGLQDDAIIVLHSDGSHGPEYYERYPKEMERFQPVCRTNQLGSCSKEELVNVYDNTILYTDHFLTKVIELLKRNADKRDTAMIYVSDHGESLGENGVYLHAAPYSIAPQAQIHVPMVMWFAPQALGNWGIQRSCLDGKRDDKDLSHDNLFHSVLGLLDVQTSLYQPALDIFASCRAPRAAQ

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016776 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor).
  • GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
  • GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
73 78 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
222 548 Gene3D G3DSA:3.40.720.10 Alkaline Phosphatase, subunit A
222 548 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily
236 530 CDD cd16017 LptA
7 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
154 176 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
177 551 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 550 PANTHER PTHR30443 INNER MEMBRANE PROTEIN
6 550 InterPro IPR040423 Phosphoethanolamine transferase
59 209 Pfam PF08019 Phosphoethanolamine transferase EptA/EptB
59 209 InterPro IPR012549 Phosphoethanolamine transferase, N-terminal
101 119 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
158 180 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
143 153 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
217 548 FunFam G3DSA:3.40.720.10:FF:000022 Phosphoethanolamine transferase eptA
237 532 SUPERFAMILY SSF53649 Alkaline phosphatase-like
237 532 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily
240 529 Pfam PF00884 Sulfatase
240 529 InterPro IPR000917 Sulfatase, N-terminal
120 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
123 145 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 48 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
79 100 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3310
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.745
12 0.33

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

35 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3EP
6LI6
A0A0R6L508 118.2 Da LogP 2.53 TPSA 0.0 ✓ Ro5 ✓ Clean CCP(CC)CC
DDQ
4KAV
Q7DD94 201.4 Da LogP 3.70 TPSA 23.1 ✓ Ro5 ✓ Clean CCCCCCCCCC[N+](C)(C)[O-]
ETA
5YLE
A0A0R6L508 61.1 Da LogP -1.06 TPSA 46.2 ✓ Ro5 ✓ Clean C(CO)N
LXC
5ZJV
A0A0R6L508 150.1 Da LogP -2.58 TPSA 90.2 ✓ Ro5 ✓ Clean C1[C@@H]([C@H]([C@@H]([C@H](O1)O)O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.