Protein profile

PA3329

hypothetical protein

Genome: NC_002516.2

Gene: PA3329 Structure source: Experimental + AlphaFold UniProt Q9HYR6
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Amino acids 442
Annotations 3
Features 8
PDB binders 2
Druggability 0.686

Overview

Basic information about this protein and its source genome.

Accession
PA3329
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3329
Status
annotated
Amino acids
442
Structure source
Experimental + AlphaFold
EC
2.3.1.282
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.686
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MMAEIRRPLSAVERWYWLSDQFSALNVISRVRVHGRLSIDDLRRGLDALQARHPLLRARIEHDAGLDPRWVPCERPIPLREVRGGGEEQWLREINERELPERIDPDSGPLIRTVAIATDAGAHDLLVVVPHIIADGTTVLTLAEQWLTLAADPAAQPWTASALPPAEDLRPRRFTGDEGAARLAEQTAQDEALVGRHRPGRIEPSNPVPLEARRTRLLHRELDGAQLEQLQRRAREHGTTVHGALTAALAIAAGHDHQRRPSHIAIGSPIDFRDELEPPVRPDEVGTYVATVPVVLDIARPFWEVARALTDDLGERRRQGHHFNLVTLVASAAPRCMADARPFMAFMEAEGPINLCSSNIGRYPFPERIGALRLSDAQFLTGISVNGYFVAAINSSHGRLFWNFTYIDEAVPGERAERLAEDCLGTLLSAIHAPQRSALEEQ

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
3 435 PANTHER PTHR28037 ALCOHOL O-ACETYLTRANSFERASE 1-RELATED
7 157 SUPERFAMILY SSF52777 CoA-dependent acyltransferases
190 434 SUPERFAMILY SSF52777 CoA-dependent acyltransferases
174 440 Gene3D G3DSA:3.30.559.30 Nonribosomal peptide synthetase, condensation domain
19 145 Pfam PF00668 Condensation domain
19 145 InterPro IPR001242 Condensation domain
4 173 Gene3D G3DSA:3.30.559.10 -
4 173 InterPro IPR023213 Chloramphenicol acetyltransferase-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8S6L
X-ray 1.55 Å A
99.8% 2-442
PDBe RCSB PDBj File
Viewing
AlphaFold PA3329
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.686
2 0.684
1 0.683

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.03 0.929
2 3.33 0.118
3 3.04 0.1
4 2.4 0.064
5 2.06 0.046

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

8 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
CO8
7C1R
E5ATN9 893.7 Da LogP 1.03 TPSA 363.6 3 viol. ✓ Clean CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO[P…
FGU
7C1S
E5ATN9 232.3 Da LogP 0.76 TPSA 72.2 ✓ Ro5 ✓ Clean CC(C)C[C@@H](C(=O)SCCNC(=O)C)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.