Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3345
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3345
Status: annotated
Amino acids: 116
Structure source: Experimental + AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009927 Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. GO:0043424 Binding to a protein histidine kinase. GO:1900191 Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0050921 Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.893

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0009927 Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator.
GO:0043424 Binding to a protein histidine kinase.
GO:1900191 Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
GO:0050921 Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
GO:2000145 Any process that modulates the frequency, rate or extent of cell motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
1	110	Gene3D	G3DSA:1.20.120.160	HPT domain
1	110	InterPro	IPR036641	HPT domain superfamily
18	116	ProSiteProfiles	PS50894	Histidine-containing phosphotransfer (HPt) domain profile.
18	116	InterPro	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain
25	100	CDD	cd00088	HPT
25	100	InterPro	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain
25	100	Pfam	PF01627	Hpt domain
3	113	SUPERFAMILY	SSF47226	Histidine-containing phosphotransfer domain, HPT domain
3	113	InterPro	IPR036641	HPT domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
PDB 7C1I	X-ray	1.58 Å	A,B,C,D,E,F	100.0% 1-116	PDBe RCSB PDBj File	Viewing
AlphaFold PA3345	AlphaFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.893

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Sticks	Spheres	Surfaces	Score	Probability	Labels	Zoom	Positions
1				1.88	0.038
2				1.55	0.023

PA3345