Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3357
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3357 dsdA
Status: annotated
Amino acids: 448
Structure source: AlphaFold

EC

4.3.1.18

GO

GO:0008721 Catalysis of the reaction: D-serine = pyruvate + NH4+. GO:0016836 Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0036088 The chemical reactions and pathways resulting in the breakdown of D-serine. GO:0006520 The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0046416 The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

4.3.1.18

Gene Ontology (GO)

6

GO:0008721 Catalysis of the reaction: D-serine = pyruvate + NH4+.
GO:0016836 Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
GO:0036088 The chemical reactions and pathways resulting in the breakdown of D-serine.
GO:0006520 The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
GO:0046416 The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
109	123	ProSitePatterns	PS00165	Serine/threonine dehydratases pyridoxal-phosphate attachment site.
109	123	InterPro	IPR000634	Serine/threonine dehydratase, pyridoxal-phosphate-binding site
117	239	Gene3D	G3DSA:3.40.50.1100	-
117	239	InterPro	IPR036052	Tryptophan synthase beta chain-like, PALP domain superfamily
1	448	Hamap	MF_01030	D-serine dehydratase [dsdA].
1	448	InterPro	IPR011780	D-serine ammonia-lyase
80	444	PANTHER	PTHR48078	THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED
97	398	Pfam	PF00291	Pyridoxal-phosphate dependent enzyme
97	398	InterPro	IPR001926	Tryptophan synthase beta chain-like, PALP domain
10	440	NCBIfam	TIGR02035	D-serine ammonia-lyase
10	440	InterPro	IPR011780	D-serine ammonia-lyase
14	441	Gene3D	G3DSA:3.40.50.1100	-
14	441	InterPro	IPR036052	Tryptophan synthase beta chain-like, PALP domain superfamily
98	440	SUPERFAMILY	SSF53686	Tryptophan synthase beta subunit-like PLP-dependent enzymes
98	440	InterPro	IPR036052	Tryptophan synthase beta chain-like, PALP domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3357	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.87

PA3357