Protein profile

PA3358

hypothetical protein

Genome: NC_002516.2

Gene: PA3358 Structure source: AlphaFold UniProt Q9HYN8
Export view
Amino acids 292
Annotations 1
Features 41
PDB binders 0
Druggability 0.893

Overview

Basic information about this protein and its source genome.

Accession
PA3358
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3358
Status
annotated
Amino acids
292
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.893
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
30 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
288 292 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
71 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 118 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
182 202 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
127 145 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
264 268 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
119 126 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41 145 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
269 287 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 286 PANTHER PTHR32322 INNER MEMBRANE TRANSPORTER
152 288 Gene3D G3DSA:1.10.3730.20 -
151 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
214 235 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
146 150 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
68 90 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
215 237 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
127 146 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
203 213 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
183 202 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
247 263 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
60 70 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
244 263 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
236 246 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 59 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 181 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91 95 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 141 Pfam PF00892 EamA-like transporter family
13 141 InterPro IPR000620 EamA domain
154 286 Pfam PF00892 EamA-like transporter family
154 286 InterPro IPR000620 EamA domain
196 291 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3358
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.647
3 0.567
11 0.381