Protein profile

PA3363

aliphatic amidase regulator

Genome: NC_002516.2

Gene: amiR PA3363 Structure source: Experimental + AlphaFold UniProt P10932
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Amino acids 196
Annotations 4
Features 15
PDB binders 0
Druggability 0.869

Overview

Basic information about this protein and its source genome.

Accession
PA3363
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
amiR PA3363
Status
annotated
Amino acids
196
Structure source
Experimental + AlphaFold
GO
GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0015976 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0034251 OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. GO:0031564 A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.869
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0015976 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
  • GO:0034251 OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.
  • GO:0031564 A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
2 196 PIRSF PIRSF036382 RR_antiterminator
2 196 InterPro IPR008327 Signal transduction response regulator, antiterminator
145 196 Gene3D G3DSA:1.10.10.10 -
145 196 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
129 190 ProSiteProfiles PS50921 ANTAR domain profile.
129 190 InterPro IPR005561 ANTAR domain
122 149 Coils Coil Coil
5 190 SUPERFAMILY SSF52172 CheY-like
5 190 InterPro IPR011006 CheY-like superfamily
11 146 PANTHER PTHR43367 -
137 190 Pfam PF03861 ANTAR domain
137 190 InterPro IPR005561 ANTAR domain
135 190 SMART SM01012 ANTAR_2
135 190 InterPro IPR005561 ANTAR domain
1 128 Gene3D G3DSA:3.40.50.2300 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1QO0
X-ray 2.25 Å D,E
99.5% 1-195
PDBe RCSB PDBj File
Viewing
AlphaFold PA3363
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.869
1 0.65