Protein profile

PA3364

aliphatic amidase expression-regulating protein

Genome: NC_002516.2

Gene: amiC PA3364 Structure source: Experimental + AlphaFold UniProt P27017
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Amino acids 385
Annotations 4
Features 14
PDB binders 5
Druggability 0.45

Overview

Basic information about this protein and its source genome.

Accession
PA3364
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
amiC PA3364
Status
annotated
Amino acids
385
Structure source
Experimental + AlphaFold
GO
GO:0033218 OBSOLETE. Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0034251 OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.45
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0033218 OBSOLETE. Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0034251 OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
10 375 SUPERFAMILY SSF53822 Periplasmic binding protein-like I
10 375 InterPro IPR028082 Periplasmic binding protein-like I
3 379 PANTHER PTHR47628 -
11 338 Gene3D G3DSA:3.40.50.2300 -
123 353 Gene3D G3DSA:3.40.50.2300 -
10 370 Pfam PF13433 Periplasmic binding protein domain
10 366 CDD cd06357 PBP1_AmiC
10 366 InterPro IPR039570 AmiC, periplasmic binding domain
30 46 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
30 46 InterPro IPR000709 Leu/Ile/Val-binding protein
237 255 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
237 255 InterPro IPR000709 Leu/Ile/Val-binding protein
71 81 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
71 81 InterPro IPR000709 Leu/Ile/Val-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1PEA
X-ray 2.10 Å A
100.0% 1-385
PDBe RCSB PDBj File
Viewing
PDB 1QO0
X-ray 2.25 Å A,B
98.7% 1-380
PDBe RCSB PDBj File
Loaded
PDB 1QNL
X-ray 2.70 Å A
97.4% 1-375
PDBe RCSB PDBj File
Loaded
AlphaFold PA3364
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.45

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.06 0.007
2 0.63 0.001
3 0.48 0.0

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
ACM
1PEA 2.10 Å Open crystal
59.1 Da LogP -0.51 TPSA 43.1 ✓ Ro5 ✓ Clean CC(=O)N
BMD
1QNL 2.70 Å Open crystal
87.1 Da LogP 0.27 TPSA 43.1 ✓ Ro5 ✓ Clean CCCC(=O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.