Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3373
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: phnN PA3373
Status: annotated
Amino acids: 185
Structure source: AlphaFold

EC

2.7.4.23

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0033863 Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+. GO:0006015 The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. GO:0019634 The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.917

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

2.7.4.23

Gene Ontology (GO)

5

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0033863 Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+.
GO:0006015 The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
GO:0019634 The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
3	148	PANTHER	PTHR23117	GUANYLATE KINASE-RELATED
2	179	Hamap	MF_00836	Ribose 1,5-bisphosphate phosphokinase PhnN [phnN].
2	179	InterPro	IPR012699	Ribose 1,5-bisphosphate phosphokinase PhnN
3	177	NCBIfam	TIGR02322	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN
3	177	InterPro	IPR012699	Ribose 1,5-bisphosphate phosphokinase PhnN
1	183	FunFam	G3DSA:3.40.50.300:FF:000979	Ribose 1,5-bisphosphate phosphokinase PhnN
3	180	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
3	180	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
1	181	Gene3D	G3DSA:3.40.50.300	-
1	181	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
2	182	SMART	SM00072	gk_7
2	182	InterPro	IPR008145	Guanylate kinase/L-type calcium channel beta subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3373	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.439
1				0.394

PA3373