Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3391
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3391 nosR
Status: annotated
Amino acids: 715
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.811

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records

Show feature table

Start	End	DB	Term	Name
1	12	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
420	438	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	24	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
7	29	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
596	613	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
459	481	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	28	SignalP_EUK	SignalP-noTM	SignalP-noTM
85	172	Pfam	PF04205	FMN-binding domain
85	172	InterPro	IPR007329	FMN-binding
1	715	PIRSF	PIRSF036354	NosR
1	715	InterPro	IPR011399	Nitrous oxide reductase expression regulator NosR
419	438	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
459	485	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
497	514	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
513	677	SUPERFAMILY	SSF54862	4Fe-4S ferredoxins
501	523	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
25	28	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
82	175	SMART	SM00900	FMN_bind_2
82	175	InterPro	IPR007329	FMN-binding
554	576	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
556	576	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
515	555	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
577	595	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
486	496	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29	419	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
614	715	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
596	613	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	28	Phobius	SIGNAL_PEPTIDE	Signal peptide region
496	542	Pfam	PF12801	4Fe-4S binding domain
496	542	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
597	643	Pfam	PF12801	4Fe-4S binding domain
597	643	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
38	714	PANTHER	PTHR30224	ELECTRON TRANSPORT PROTEIN
439	458	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3391	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.811
4				0.729

PA3391